Basically, this comic is a remaster of the first comic with updated art that more closely resembled the later parts. The story doesn't really change from the original part, just some of the finer details.
As for Frisky's red eyes, he just has red eyes. It could be referencing the fact that he did a genocide run prior, but since he had red eyes before he even fell into the Underground, it likely isn't.
Basically, this comic is a remaster of the first comic with updated art that more closely resembled the later parts. The story doesn't really change from the original part, just some of the finer details.
As for Frisky's red eyes, he just has red eyes. It could be referencing the fact that he did a genocide run prior, but since he had red eyes before he even fell into the Underground, it likely isn't.